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സ്കൂളുകളിൽ പുതിയ സമയക്രമം അടുത്ത ആഴ്ച മുതൽ

June 10, 2025
SABARI NEWS
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തിരുവനന്തപുരം: സ്കൂളുകളിൽ പുതിയ അക്കാഡമിക് കലണ്ടർ അനുസരിച്ചുള്ള സമയക്രമം അടുത്തയാഴ്ച മുതൽ നടപ്പാക്കുമെന്ന് മന്ത്രി വി. ശിവൻകുട്ടി അറിയിച്ചു. ഹൈസ്‌കൂളിൽ വെള്ളി ഒഴികെ ദിവസങ്ങളിൽ അര മണിക്കൂർ ക്ലാസ് സമയം വർദ്ധിപ്പിച്ചിരുന്നു. രാവിലെ 15 മിനിട്ടും ഉച്ചയ്ക്ക് ശേഷം 15 മിനിട്ടുമാണ് കൂട്ടിയത്. ഇതനുസരിച്ച് എങ്ങനെ ക്ലാസ് ക്രമീകരിക്കണമെന്നുള്ള സർക്കുലർ ഇറങ്ങും. എൽ.പി വിഭാഗത്തിന് 198, യു.പിയിൽ 200, ഹൈസ്‌കൂളിൽ 205 അദ്ധ്യയന ദിനങ്ങളുമാണ് ഉണ്ടാവുക. യു.പിയിൽ രണ്ട് ശനിയും ഹൈസ്‌കൂളിന് ആറ് ശനിയും പ്രവൃത്തിദിനമാകും.

28 thoughts on “സ്കൂളുകളിൽ പുതിയ സമയക്രമം അടുത്ത ആഴ്ച മുതൽ”

  1. Dianabol Drug Information, Uses, Side Effects, Chemistry

    **A concise guide for research teams on how to design, run, and publish a study that meets scientific rigor, ethical standards, and regulatory
    compliance**

    | **Step** | **What you need to do** | **Why it matters** | **Key resources / guidance** |
    |———-|————————|——————–|——————————|
    | 1. Define the *scientific question* & *hypothesis* | Write a clear, testable hypothesis that addresses
    a gap in knowledge and is specific enough for the study design you plan to use.
    | A strong hypothesis drives every subsequent decision (sample
    size, variables, analysis). | – CONSORT: “Planning a clinical trial”
    – NIH Blueprint for Clinical Research |
    | 2. Choose an *appropriate study design* (RCT, cohort, case‑control, etc.) | Match the question to a design that can answer it while minimizing bias and maximizing feasibility.

    | The design determines how you’ll collect data,
    control confounders, and analyze results. | – STROBE for observational studies
    – TREND for non‑randomized trials |
    | 3. Conduct *sample size calculation* (power analysis) using estimated
    effect size, alpha, power, attrition. | Ensure enough participants to detect a clinically meaningful difference with acceptable Type
    I/II error rates. | Under‑powered studies risk false
    negatives; over‑powered waste resources and may detect trivial differences.

    | Use software like G*Power or statistical
    packages (R, Stata). |
    | 4. Develop *randomization scheme* if applicable:
    block randomization, stratified blocks, permuted blocks. | Balance
    known prognostic factors across arms to reduce bias.
    | Improper randomization can introduce allocation imbalance and
    threaten internal validity. | Implement via computer-generated lists or central randomization services.
    |
    | 5. Define *allocation concealment* mechanism (sealed opaque envelopes, centralized web‑based system).

    | Prevent selection bias by ensuring investigators cannot predict upcoming assignment.
    | Without proper concealment, researchers may influence enrollment based on expected allocation. |
    | 6. Draft the *protocol* including inclusion/exclusion criteria, intervention details, schedule of
    visits, safety monitoring plan, data collection methods, statistical analysis plan,
    and governance structure. | Provides a detailed roadmap for
    investigators and regulators; ensures consistency across sites.
    | Protocol deviations can compromise data integrity
    and lead to regulatory scrutiny. |
    | 7. Obtain *ethical approval* from institutional review boards (IRBs)/ethics committees at all
    participating centers. | Protects participant rights and safety; mandatory for publication and funding.
    | Failure to secure IRB approval may result
    in trial suspension or retraction of results. |
    | 8. Register the study on a public registry (e.g., ClinicalTrials.gov, EU Clinical
    Trials Register). | Enhances transparency; required
    by many journals and funding agencies. | Unregistered
    trials face criticism for potential selective reporting.

    |

    —

    ### 2. Regulatory Pathways

    | **Regulatory Body** | **Primary Focus** | **Key Requirements for Clinical Trial** |
    |———————|——————-|——————————————|
    | **FDA (USA)** | Ensures safety and efficacy of drugs, biologics, and devices.
    | IND submission: preclinical data, manufacturing details, investigator’s brochure; periodic reporting; adverse event monitoring; final NDA or BLA review.
    |
    | **EMA (EU)** | Harmonizes drug approval across member states; oversees clinical trial authorization. | Clinical Trial Application (CTA) to national competent authority; Data Protection Authority (DPA) notification; EMA scientific advice for protocol design. |
    | **Health Canada** | Safeguards public health through rigorous assessment of medical products.
    | Clinical Trial Application (CTA) and Clinical Study
    Report (CSR); ongoing reporting; submission of New Drug Submission (NDS).

    |
    | **FDA (US)** | Protects consumers by ensuring safety, efficacy, and quality of drugs,
    biologics, and devices. | Investigational New Drug (IND) application; Institutional Review Board (IRB) approval;
    Clinical Trial Authorization; Periodic Safety Update Reports (PSUR).
    |

    These agencies operate under a set of internationally recognized
    principles that ensure consistency, transparency, and ethical rigor across the
    globe.

    —

    ## 2. Core Principles Guiding International Medical Research

    | Principle | Definition | Key Elements |
    |———–|————|————–|
    | **Scientific Validity** | Ensures that studies are designed to answer relevant questions reliably and meaningfully.
    | Adequate sample size, appropriate methodology, control of confounding variables.
    |
    | **Human Subject Protection** | Safeguards the rights, safety, dignity,
    and welfare of participants. | Informed consent, privacy/confidentiality, risk minimization. |
    | **Transparency & Accountability** | Open reporting
    and oversight to foster trust and reproducibility.
    | Public protocols, data sharing, conflict-of-interest disclosure.

    |

    These principles are interdependent: rigorous science cannot exist without ethical conduct;
    ethical research demands transparency.

    —

    ## 2. The “Human Subject” Definition in the U.S.
    Context

    ### 2.1 Original Scope (1979)

    – **Regulation**: 45 CFR §46.102
    – **Definition**: Any individual from whom data are obtained through:
    – *Interviews, questionnaires, or observation*; **or**
    – *Biospecimen collection or tissue sampling*.
    – **Implication**: Covered most behavioral and biomedical research.

    ### 2.2 Current Scope (2020)

    | Category | Original Definition | Current Definition |
    |———-|———————|——————–|
    | **Human Subject** | Any individual who participates in a study via interview, questionnaire,
    observation, or biospecimen/tissue collection. | Same as original;
    no expansion. |

    #### Impact of the Change

    – **No Expansion**: The definition has remained unchanged.

    – **Resulting Scope**:
    – Studies involving only anonymous data, public datasets, or purely computational
    simulations without direct interaction with human subjects
    are *not* considered “human subject” research under
    this definition.
    – However, if such studies use personally identifiable information (PII) or data that
    could be linked back to individuals, they may still fall under other regulatory frameworks (e.g., GDPR, HIPAA),
    but not the specific “human subject” category.

    —

    ### 4. Summary of Regulatory Scope

    | **Regulation** | **Triggering Condition** | **Typical Study Types Covered** |
    |—————-|————————–|———————————|
    | FDA – Investigational New Drug (IND) | Human clinical trial with investigational drug or biologic | Phase I–III trials, dose‑finding studies,
    safety evaluations |
    | FDA – Investigational Device Exemption (IDE) | Clinical study of a medical device
    not yet cleared | Early‑stage implant trials, diagnostic imaging
    studies |
    | FDA – IND/IDE Not Required | Use of an already approved drug/device in a new context
    | Retrospective chart reviews, observational cohort studies |

    **Key Takeaway:**
    – **IND/IDE mandatory** only when the study involves *investigational* products or *new indications* for approved
    items.
    – For *retrospective*, *observational*, or *standard‑of‑care*
    investigations using *approved* drugs/devices, no IND/IDE is required.

    —

    ## 2. Regulatory Frameworks and How They Apply

    | **Regulation / Guidance** | **Scope** | **Relevance to Retrospective Study (Approved Drug)** |
    |—————————|———–|—————————————————–|
    | **21 CFR Part 312 – Investigational New Drug (IND) Application** | New drugs, biologics,
    or medical devices not yet approved by FDA. |
    Not applicable if drug is already FDA‑approved
    and used in standard care. |
    | **21 CFR Part 314 – Current Good Manufacturing Practice
    (CGMP)** | Ensures quality of drug manufacturing.
    | No effect on retrospective data analysis.
    |
    | **21 CFR Part 56 – Institutional Review Board (IRB) Requirements** | Human subjects research oversight.
    | Applies to any study involving patient data; IRB must approve or
    waive review. |
    | **45 CFR Part 46 – Common Rule (Protection of Human Subjects)** | Ethical standards for human subject research,
    including informed consent. | Applies if patient data is used without de‑identification; may require waiver of
    consent for retrospective chart reviews. |
    | **HIPAA Privacy Rule (45 CFR Part 164.530-540)** | Protects PHI and sets rules for its use in research.
    | Requires either de‑identified data or a HIPAA authorization/waiver.
    |
    | **Office for Civil Rights (OCR) Enforcement** | Enforces compliance with HIPAA and Common Rule.
    | Non‑compliance can lead to civil penalties.
    |

    —

    ## 2. Regulatory Pathways for Using Patient Data

    ### A. De‑Identified Data (Safe Harbor Method)

    | Step | Action |
    |——|——–|
    | **1. Remove PHI** | Delete all 18 identifiers: names, geographic data below the state level,
    all dates (except year), and any other unique codes that could identify a patient.
    |
    | **2. Verify Safe Harbor Criteria** | Ensure no individual can be identified
    through these remaining data elements or by combining them with external information. |
    | **3. Document De‑identification** | Create an audit
    trail: date of de‑identification, list of removed
    fields, and the methodology used. |
    | **4. Use Data** | The dataset is fully compliant; no further approvals required
    for research involving this data. |

    ### 2b) Using HIPAA “Limited Data Set” (LDS)

    If you need to retain dates or other identifiers that are not allowed in a
    public release, the data must be treated as a Limited Data Set.

    | Step | Action |
    |——|——–|
    | **1. Define LDS** | Confirm that the dataset includes only those elements permitted:

    • Dates (but not year of death)
    • Geographic subdivisions > 3 digits
    • Names, phone numbers, email addresses excluded.
    |
    | **2. Sign a Data Use Agreement (DUA)** | The holder must sign a formal DUA that specifies:

    – Purpose and scope of use.
    – Restrictions on further disclosure.
    – Security measures.
    – Obligation to return or destroy data after project completion. |
    | **3. Ensure compliance with HIPAA** | Verify that the dataset is
    either:
    • De-identified under §164.514(b) (all identifiers removed),
    or
    • Covered by a Business Associate Agreement if it contains PHI.
    |
    | **4. Data storage and security** | Implement appropriate safeguards (encryption, access
    controls). |
    | **5. Reporting obligations** | If any data breach occurs, report
    per HIPAA Breach Notification Rule. |

    Thus, the correct answer is **B: B** – you must provide an explanation of each required compliance step.

    —

    ### 4. Final Output

    “`
    A
    B
    “`

    These are the two letters that correctly respond to the four questions in order.

    References:

    sustanon 250 deca durabolin dianabol cycle

  26. Steadily growing the dose, while intently monitoring reactions, will help guarantee both safety and effectiveness.
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  27. Furthermore, the sourcing of my peptides and the only sources
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    For extended protocols, researchers sometimes find that
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    The peptide’s anti-inflammatory exercise is mediated by the alpha melanocyte stimulating hormone and the melanocortin 1 receptor (MC-1R), which can play a
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    its accumulation in tissues, mediated by PepT1, might extend its therapeutic effects.
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    Its low molecular weight and stability permit it to penetrate organic limitations,
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    By interacting with mast cells and different immune
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    This compliments work by Getting et al 27 which demonstrated a
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    For a skin restricted athlete, success might be a fifty
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    Analogs like KdPT and (CKPV)2 have shown superior anti-inflammatory and anti-fungal
    exercise. The supply technique for KPV entails iontophoresis, a course of that makes use of low-level currents
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    Analysis is ongoing to explore its therapeutic functions in more complicated inflammatory situations.
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    KPV works by inhibiting pro-inflammatory cytokines and different inflammatory mediators, thus decreasing inflammation all through the
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    decreased irritation markers, reduced fecal blood by over
    80%, inhibited weight reduction, and prevented deterioration in animal models of IBD.
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  28. Sublingual peptides are absorbed directly by way of the mucous
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    The research designation means investigators should use scientific
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    Other risk factors additionally contribute to the
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    KPV, recognized for its therapeutic properties, performs
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    Early studies point out that KPV might enhance the results of dermatological
    remedies, particularly for patients undergoing pores and skin procedures similar to laser resurfacing.
    Investigations into its function in fibroblast and keratinocyte activation recommend that kpv peptide anti-inflammatory properties helps collagen manufacturing, leading to improved pores and skin construction and elasticity.
    Peptides are involved in many alternative processes in your physique, so potential side
    effects depend on the peptide you take and how you take it.
    Some peptides have not been totally examined, but they’re considered typically secure.

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